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@Austin
Your implementation will depend on how you want to make the editor accessible. I haven't seen anything added to the Wordpress Codex regarding Media Page-related filters, but that doesn't mean they don't exist. If they do, you might be able to use those hooks to call Pixlr instead of the default editor quite easily.

Otherwise, you'll want to do a variation on what I've done. I've insert a button (using WP filter hooks or by modifying the DOM using Javascript) that pulls the image you want to edit into Pixlr in the Post/Page edit page. Getting the image data is done relatively easily using the Pixlr API and an Ajax call (http://www.pixlr.com/wiki/developer/api).

WP natively supports Thickbox so you can use it to create a window into which the editor will appear; you just have to make sure Thickbox is loaded with the Admin panel you are accessing. Call Pixlr into a Thickbox window, referencing the image you want to edit. When Pixlr exits, it will POST the image data back to you -- as you close the Thickbox window, replace the old image with the new one, and - if there is a visible thumbnail - make sure it's updated as well.