Brizzly: full-featured web client for Twitter
On the plus side, Brizzly allows you to save drafts of tweets, a feature I wish Twitter.com would incorporate. Its threaded interface for direct messages is also nice, and looks a bit like a Google Talk window. If you DM a lot, Brizzly will definitely make it easier to follow your conversations. Brizzly also tells you when there are new tweets in your stream, so you're not fruitlessly hitting refresh to read Twitter. Keyboard shortcuts are handy, too: The j and k keys scroll up and down, which Gmail and Google Reader users will be familiar with. On top of that, photos and videos are displayed inline, instead of making you click through.
Brizzly's not all great, though. It's unfortunately just not a very pretty website, and I don't think I can look at it every day. I'm not saying we're in Fugly Friday territory, but the design is weak, especially the prominent trending topics box. I also miss having my follower/following numbers and my friends' icons in the sidebar, the way Twitter.com does it. Some people might find that useless, but I would say the same about trending topics. It's all a matter of taste, so if Brizzly's array of features fits your needs, and you don't mind its appearance, you should definitely give it a shot.