Streamfile does painless point-to-point transfers with 256-bit encryption
For those of you who need to send even larger files, there are two options. The free registered account gives you a 300Mb maximum, 48 hour expiration, and 5 concurrent download links.
Still not enough? $4.95 per month (or $39.95/year) gets you a 2Gb max, no limit on links, and expiration extends to a full two weeks. On top of that, you'll get delivery tracking and "more bandwidth," though no information is given as to what that actually means.
One thing worth noting in the TOS: "We may, however, also use your email address or other personally identifiable information to send commercial or marketing messages without your consent. Your e-mail address may also be made accessible to third parties with which Streamfile has entered agreements."
Mail delivery preferences can be changed in your account preferences, so head there and untick the necessary box to opt out.