Chirp is a stunning Windows Twitter client, if you have tons of ram
Right now I'm using Pidgin-Twitter, which doesn't look this good until you have three or four pints. While Pidgin might not be much to look at, at least it doesn't use anywhere close to 100Mb of memory.
No, I'm not kidding.
Fire up Chirp, and you'll see memory usage in task manager rocket past that mark. On my system, it peaked at 204Mb for a few seconds, and then fell back to a more reasonable 114Mb - still a bit much for a Twitter client.
I'm really hoping that the developers can sort this out, though, because Chirp's visuals are fantastic, and it's one of the nicest desktop Twitter apps I've used. No functionality has been missed, with support for updates, direct messages, replies, retweets, profile viewing, and favorites.
In all honesty, I've got more than enough memory to spare for running Chirp. It's just offputting because other applications - like Photoshop, Firefox, or Chrome - can do an awful lot more than interface with Twitter using the same amount.
Still, Chirp is worth a look based on the interface alone. It's the kind of eye candy not normally seen in Windows applications. If you'd like to see some more screens before you take the plunge, check the gallery after the break.
Chirp is a free download, and you'll also need .net installed to try it out.