Shutterbook: Another player in the photo-sharing arena
Shutterbook, a photo sharing and management site, may be accused of bandwagon-jumping, but it does have a great interface going for it. It's mostly Flash-based, but is attractive and responsive. It lacks the community aspect that attracts the Flickr crowd, which may be a big turn-off for some, but does allow comments and has a blog featured. Shutterbook is currently in private beta, and there's a reasonably good demo you can check out before registering.
